دورية أكاديمية
Diagnostic sensitivity of RT-PCR assays on nasopharyngeal specimens for detection of SARS-CoV-2 infection: A Systematic Review and Meta-Analysis
| العنوان: | Diagnostic sensitivity of RT-PCR assays on nasopharyngeal specimens for detection of SARS-CoV-2 infection: A Systematic Review and Meta-Analysis |
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| المؤلفون: | Marco Marando, Adriana Tamburello, Pietro Gianella, Rebecca Taylor, Enos Bernasconi, Tanja Fusi-Schmidhauser |
| المصدر: | Caspian Journal of Internal Medicine, Vol 13, Iss Covid 19 Supplement 2, Pp 139-147 (2022) |
| بيانات النشر: | Babol University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | nasopharyngeal swabs, sars-cov-2, rt-pcr assay, diagnostic yield., Internal medicine, RC31-1245 |
| الوصف: | Background: Reverse transcription polymerase chain reaction (RT-PCR) is the current standard of reference in the diagnosis of SARS-CoV-2 infection. In outpatient clinical practice, nasopharyngeal swab RT-PCR testing is still the most common procedure. The purpose of this systematic review and meta-analysis was to evaluate the sensitivity of RT-PCR nasopharyngeal assays. Methods: We searched three databases, including PubMed/MEDLINE, EMBASE, and Cochrane Library, using a comprehensive strategy. Studies investigating the sensitivity of SARS-CoV-2 RT-PCR nasopharyngeal assays in adults were included. Two reviewers extracted data and assessed trial quality independently. Pooled sensitivity and its confidence interval were computed using the meta package in R. Results: Thirteen studies were found eligible for the inclusion in the systematic review. Out of these, 25 different sub-studies were identified and included in the meta-analysis, which reported the sensitivities of 25 different nasopharyngeal RT-PCR assays. Finally, the overall pooled sensitivity resulted 89% (95% CI, 85.4 to 91.8%). Conclusion: Our study suggests that RT-PCR assays on nasopharyngeal specimens have a substantial sensitivity for diagnosing SARS-CoV-2 infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-6164 2008-6172 |
| Relation: | http://caspjim.com/article-1-2969-en.html; https://doaj.org/toc/2008-6164; https://doaj.org/toc/2008-6172 |
| URL الوصول: | https://doaj.org/article/e32351df5c36490eb1813442e31e685c |
| رقم الأكسشن: | edsdoj.32351df5c36490eb1813442e31e685c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20086164 20086172 |
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