دورية أكاديمية
Implantation of nanofibrous silk scaffolds seeded with bone marrow stromal cells promotes spinal cord regeneration (6686 words)
| العنوان: | Implantation of nanofibrous silk scaffolds seeded with bone marrow stromal cells promotes spinal cord regeneration (6686 words) |
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| المؤلفون: | Xin-Hong Wang, Xiao-Chen Tang, Xia Li, Jian-Zhong Qin, Wen-Tao Zhong, Peng Wu, Feng Zhang, Yi-Xin Shen, Ting-Ting Dai |
| المصدر: | Artificial Cells, Nanomedicine, and Biotechnology, Vol 49, Iss 1, Pp 699-708 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Spinal cord injury, silk fibroin, nanofibrous structure, porous scaffold, mesenchymal stem cells, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Spinal cord injury (SCI) is a common pathology often resulting in permanent loss of sensory, motor, and autonomic function. Numerous studies in which stem cells have been transplanted in biomaterial scaffolds into animals have demonstrated their considerable potential for recovery from SCI. In the present study, a three-dimensional porous silk fibroin (SF) scaffold with a mean pore size of approximately 383 μm and nanofibrous structure was fabricated, the silk scaffold enabling the enhanced attachment and proliferation of bone marrow stromal cells (BMSCs). Investigation of its therapeutic potential was conducted by implantation of the nanofibrous SF scaffold seeded with BMSCs into a transected spinal cord model. Recovery of the damaged spinal cord was significantly improved after 2 months, compared with a non-nanofibrous scaffold, in combination with decreased glial fibrillary acidic protein (GFAP) expression and improved axonal regeneration at the site of injury. Furthermore, elevated Basso-Beattie-Bresnahan (BBB) scores indicated greatly improved hindlimb movement. Together, these results demonstrate that transplantation of neural scaffolds consisting of nanofibrous SF and BMSCs is an attractive strategy for the promotion of functional recovery following SCI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 21691401 2169-141X 2169-1401 |
| Relation: | https://doaj.org/toc/2169-1401; https://doaj.org/toc/2169-141X |
| DOI: | 10.1080/21691401.2021.2013250 |
| URL الوصول: | https://doaj.org/article/3238a2265e3d4382a9648703d59ed392 |
| رقم الأكسشن: | edsdoj.3238a2265e3d4382a9648703d59ed392 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21691401 2169141X |
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| DOI: | 10.1080/21691401.2021.2013250 |