دورية أكاديمية
Crohn's disease and smoldering multiple myeloma: a case report and literature review
| العنوان: | Crohn's disease and smoldering multiple myeloma: a case report and literature review |
|---|---|
| المؤلفون: | So Young Park, Jae Min Kim, Hyun Joon Kang, Minje Kim, Jae Joon Han, Chi Hoon Maeng, Sun Kyung Baek, Hwi-Joong Yoon, Si-Young Kim, Hyo Jong Kim |
| المصدر: | Intestinal Research, Vol 15, Iss 2, Pp 249-254 (2017) |
| بيانات النشر: | Korean Association for the Study of Intestinal Diseases, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Crohn disease, Multiple myeloma, Tumor necrosis factor-alpha, Medicine, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) that presents with abdominal pain, weight loss, and diarrhea. Although the etiology has not been fully elucidated, both environmental and genetic causes are known to be involved. In chronic inflammatory conditions such as IBD, B lymphocytes are chronically stimulated, and they induce monoclonal expansion of plasma cells, sometimes resulting in monoclonal gammopathy of undetermined significance. Immunomodulators that are commonly used to control inflammation, such as tumor necrosis factor-α (TNF-α) blockers could increase the possibility of hematologic malignancy. The pathogenesis of multiple myeloma in association with TNF-α inhibitor therapy is attributed to decreased apoptosis of plasma cell populations. Here, we describe a case of a 36-year-old male patient who was diagnosed with immunoglobulin A subtype smoldering multiple myeloma during the treatment for CD with infliximab and adalimumab. We report this case along with a review of the literature on cases of multiple myeloma that occurred in conjunction with CD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1598-9100 |
| Relation: | https://doaj.org/toc/1598-9100 |
| DOI: | 10.5217/ir.2017.15.2.249 |
| URL الوصول: | https://doaj.org/article/aa32424246814fcc98f4df6d20f9719e |
| رقم الأكسشن: | edsdoj.32424246814fcc98f4df6d20f9719e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15989100 |
|---|---|
| DOI: | 10.5217/ir.2017.15.2.249 |