دورية أكاديمية
The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer
العنوان: | The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer |
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المؤلفون: | Jack Gudgeon, José Luis Marín-Rubio, Matthias Trost |
المصدر: | Frontiers in Immunology, Vol 13 (2022) |
بيانات النشر: | Frontiers Media S.A., 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Immunologic diseases. Allergy |
مصطلحات موضوعية: | MSR1, CD204, macrophages, immunology, cancer, inflammation, Immunologic diseases. Allergy, RC581-607 |
الوصف: | Macrophage scavenger receptor 1 (MSR1), also named CD204, holds key inflammatory roles in multiple pathophysiologic processes. Present primarily on the surface of various types of macrophage, this receptor variably affects processes such as atherosclerosis, innate and adaptive immunity, lung and liver disease, and more recently, cancer. As highlighted throughout this review, the role of MSR1 is often dichotomous, being either host protective or detrimental to the pathogenesis of disease. We will discuss the role of MSR1 in health and disease with a focus on the molecular mechanisms influencing MSR1 expression, how altered expression affects disease process and macrophage function, the limited cell signalling pathways discovered thus far, the emerging role of MSR1 in tumour associated macrophages as well as the therapeutic potential of targeting MSR1. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-3224 |
Relation: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012002/full; https://doaj.org/toc/1664-3224 |
DOI: | 10.3389/fimmu.2022.1012002 |
URL الوصول: | https://doaj.org/article/33580f7b62a54f1ebb7e27d63222ef3b |
رقم الأكسشن: | edsdoj.33580f7b62a54f1ebb7e27d63222ef3b |
قاعدة البيانات: | Directory of Open Access Journals |
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