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Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure.

التفاصيل البيبلوغرافية
العنوان: Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure.
المؤلفون: Jody A Rule, Linda S Hynan, Nahid Attar, Corron Sanders, William J Korzun, William M Lee, Acute Liver Failure Study Group
المصدر: PLoS ONE, Vol 10, Iss 9, p e0138566 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Because acute liver failure (ALF) patients share many clinical features with severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is challenging. Procalcitonin (PCT) has proven to be a useful marker in detecting bacterial infection. We sought to determine whether PCT discriminated between presence and absence of infection in patients with ALF.Retrospective analysis of data and samples of 115 ALF patients from the United States Acute Liver Failure Study Group randomly selected from 1863 patients were classified for disease severity and ALF etiology. Twenty uninfected chronic liver disease (CLD) subjects served as controls.Procalcitonin concentrations in most samples were elevated, with median values for all ALF groups near or above a 2.0 ng/mL cut-off that generally indicates severe sepsis. While PCT concentrations increased somewhat with apparent liver injury severity, there were no differences in PCT levels between the pre-defined severity groups-non-SIRS and SIRS groups with no documented infections and Severe Sepsis and Septic Shock groups with documented infections, (p = 0.169). PCT values from CLD patients differed from all ALF groups (median CLD PCT value 0.104 ng/mL, (p ≤0.001)). Subjects with acetaminophen (APAP) toxicity, many without evidence of infection, demonstrated median PCT >2.0 ng/mL, regardless of SIRS features, while some culture positive subjects had PCT values
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4579124?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0138566
URL الوصول: https://doaj.org/article/ea3505d02f6a450c88059ff83b6cac18
رقم الأكسشن: edsdoj.3505d02f6a450c88059ff83b6cac18
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0138566