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The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases

التفاصيل البيبلوغرافية
العنوان: The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases
المؤلفون: Liu N, Dong J, Li L, Zhou D, Liu F
المصدر: Journal of Inflammation Research, Vol Volume 17, Pp 1607-1619 (2024)
بيانات النشر: Dove Medical Press, 2024.
سنة النشر: 2024
المجموعة: LCC:Pathology
LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: osteolysis, bone resorption, bone loss, metrnl, arthritis, stiff elbow, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
الوصف: Nan Liu, Jinlei Dong, Lianxin Li, Dongsheng Zhou, Fanxiao Liu Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of ChinaCorrespondence: Fanxiao Liu, Department of Orthopedics, Shandong Provincial Hospital affiliated to Shandong First Medical University, No. 324, Road Jing Wu Wei Qi, Jinan, Shandong, 250021, People’s Republic of China, Tel +86-15069058755, Email woshi631@126.comAbstract: Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal role in counteracting obesity-induced insulin resistance. It enhances adipose tissue functionality by promoting adipocyte differentiation, activating metabolic pathways, and exerting anti-inflammatory effects. Extensive research has identified Metrnl as a key player in modulating inflammatory responses and as an integral regulator of muscle regeneration. These findings position Metrnl as a promising biomarker and potential therapeutic target in treating inflammation-associated pathologies. Despite this, the specific anti-inflammatory mechanisms of Metrnl in immune-mediated osteolysis and arthritis remain elusive, warranting further investigation. In this review, we will briefly elaborate on the role of Metrnl in anti-inflammation function in inflammation-related osteolysis, arthritis, and pathological bone resorption, which could facilitate Metrnl’s clinical application as a novel therapeutic strategy to prevent bone loss. While the pathogenesis of elbow stiffness remains elusive, current literature suggests that Metrnl likely exerts a pivotal role in its development.Keywords: osteolysis, bone resorption, bone loss, Metrnl, arthritis, stiff elbow
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-7031
Relation: https://www.dovepress.com/the-function-and-mechanism-of-anti-inflammatory-factor-metrnl-prevents-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031
URL الوصول: https://doaj.org/article/365b18ba52014f67b30c3986de5232fb
رقم الأكسشن: edsdoj.365b18ba52014f67b30c3986de5232fb
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11787031