دورية أكاديمية
Secondary bile acids effects in colon pathology. Experimental mice study
| العنوان: | Secondary bile acids effects in colon pathology. Experimental mice study |
|---|---|
| المؤلفون: | Claudiu Saracut, Calin Molnar, Cristian Russu, Nicoleta Todoran, Laurian Vlase, Sabin Turdean, Septimiu Voidazan, Constantin Copotoiu |
| المصدر: | Acta Cirúrgica Brasileira, Vol 30, Iss 9, Pp 624-631 (2015) |
| بيانات النشر: | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Surgery |
| مصطلحات موضوعية: | Deoxycholic Acid, Lithocholic Acid, Colon, Mice, Surgery, RD1-811 |
| الوصف: | ABSTRACTPURPOSE:To assess whether deoxycholic acid (DOC) and lithocholic acid (LCA) administered in a period of six months in a concentration of 0.25% may have a carcinogenic role in mice colon.METHODS:The study used C57BL6 female mice divided into four groups. The control group received a balanced diet and the others received diets supplemented with 0.25% DOC, 0.25% LCA and 0.125% DOC+0.125% LCA, respectively. After euthanasia, the lesions found in the resected gastrointestinal tracts were stained with hematoxylin-eosin and examined microscopically.RESULTS:No gastrointestinal tract changes were observed in the control group, while hyperplastic Peyer's patches in the small intestine, flat adenomas with mild dysplasia and chronic colitis at the level of the colon were found in all three test groups. The colonic lesions prevailed in the proximal colon. The highest number of flat adenoma lesions (8), hyperplasia of Peyer's patches (25) and chronic colitis (2) were found in mice fed with diet and LCA.CONCLUSION: Precancerous or cancerous pathological lesions could not be identified. Instead, adenomatous colonic injuries occurred in a shorter period of time (six months), compared to the reported data. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0102-8650 |
| Relation: | http://www.scielo.br/pdf/acb/v30n9/0102-8650-acb-30-09-00624.pdf; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000900624&tlng=en; https://doaj.org/toc/0102-8650 |
| DOI: | 10.1590/S0102-865020150090000007 |
| URL الوصول: | https://doaj.org/article/a37029898af44ee4aec64ed4615bc6d3 |
| رقم الأكسشن: | edsdoj.37029898af44ee4aec64ed4615bc6d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
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