دورية أكاديمية
Confirmation of antiphospholipid antibody positivity: a year’s results in a cohort of 113 patients
العنوان: | Confirmation of antiphospholipid antibody positivity: a year’s results in a cohort of 113 patients |
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المؤلفون: | A. Ruffatti, E. Salvan, S. Olivieri, A. Bontadi, M. Tonello, T. Del Ross, S. Cuffaro, L. Punzi |
المصدر: | Reumatismo, Vol 62, Iss 1, Pp 51-59 (2011) |
بيانات النشر: | PAGEPress Publications, 2011. |
سنة النشر: | 2011 |
المجموعة: | LCC:Medicine LCC:Internal medicine |
مصطلحات موضوعية: | Medicine, Internal medicine, RC31-1245 |
الوصف: | Objective: To evaluate the confirmation rate of antiphospholipid antibodies (aPL), to analyze their behaviour at confirmation time, and to study the clinical value of their confirmation. Methods: Blood samples from 380 subjects, enrolled in this study from June 1, 2007 to May 31, 2008, were tested for anti-cardiolipin (aCL) and anti-beta2glycoprotein (aβ2GPI) antibodies using an ELISA method and for Lupus anticoagulant (LA) using a series of clotting tests. The samples of the 113 subjects resulting positive at the first testing time were assayed again to confirm antiphospholipid positivity. Results: aPL positivity was confirmed in 67 out of the 113 subjects (59.3%). Medium-high antibody levels of all, except IgM aCL, aPL/ELISA had a significantly higher confirmation rate with respect to that in subjects with low levels. The confirmation rate in the category I antibody patients (multiple positivity) was higher than that in the category II antibody subjects (single positivity). LA positivity was confirmed only when it was associated to other aPL. The cut-off of 40 GPL produced a confirmation rate equal to that resulting from a 99th percentile cut-off. Confirmation of aPL positivity made it possible for us to confirm the diagnosis of antiphospholipid syndrome (APS) in 8 out of the 113 subjects originally resulting positive (7,1%). APS clinical features were vascular thrombosis in 4 of these and pregnancy morbidity in the other 4. Conclusions: Our data emphasize aPL positivity confirmation selectivity, and medium-high antibody levels and category I antibodies (multiple positivity) had the best confirmation rates. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English Italian |
تدمد: | 0048-7449 2240-2683 |
Relation: | http://www.reumatismo.org/index.php/reuma/article/view/463; https://doaj.org/toc/0048-7449; https://doaj.org/toc/2240-2683 |
DOI: | 10.4081/reumatismo.2010.51 |
URL الوصول: | https://doaj.org/article/3786eb1a0548485cad415d83e12aaf9e |
رقم الأكسشن: | edsdoj.3786eb1a0548485cad415d83e12aaf9e |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 00487449 22402683 |
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DOI: | 10.4081/reumatismo.2010.51 |