دورية أكاديمية
The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease
العنوان: | The Controversial Role of Fibrosis in Autosomal Dominant Polycystic Kidney Disease |
---|---|
المؤلفون: | Maria Fragiadaki, Fiona M. Macleod, Albert C. M. Ong |
المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 23, p 8936 (2020) |
بيانات النشر: | MDPI AG, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | ADPKD, fibrosis, EMT, TGFβ, JAK/STAT, hypoxia, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the progressive growth of cysts but it is also accompanied by diffuse tissue scarring or fibrosis. A number of recent studies have been published in this area, yet the role of fibrosis in ADPKD remains controversial. Here, we will discuss the stages of fibrosis progression in ADPKD, and how these compare with other common kidney diseases. We will also provide a detailed overview of some key mechanistic pathways to fibrosis in the polycystic kidney. Specifically, the role of the ‘chronic hypoxia hypothesis’, persistent inflammation, Transforming Growth Factor beta (TGFβ), Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and microRNAs will be examined. Evidence for and against a pathogenic role of extracellular matrix during ADPKD disease progression will be provided. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 21238936 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/21/23/8936; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms21238936 |
URL الوصول: | https://doaj.org/article/378e396ab21e4fe99d60004c487c403a |
رقم الأكسشن: | edsdoj.378e396ab21e4fe99d60004c487c403a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21238936 14220067 16616596 |
---|---|
DOI: | 10.3390/ijms21238936 |