دورية أكاديمية
Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
| العنوان: | Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response |
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| المؤلفون: | Jieya Shao |
| المصدر: | Molecular & Cellular Oncology, Vol 7, Iss 5 (2020) |
| بيانات النشر: | Taylor & Francis Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | proteostasis, dna damage response, chemotherapy, phosphorylation, prognostic biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2372-3556 23723556 |
| Relation: | https://doaj.org/toc/2372-3556 |
| DOI: | 10.1080/23723556.2020.1796179 |
| URL الوصول: | https://doaj.org/article/38005bffac504a7f9bd0331a8ca3a5f4 |
| رقم الأكسشن: | edsdoj.38005bffac504a7f9bd0331a8ca3a5f4 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 23723556 |
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| DOI: | 10.1080/23723556.2020.1796179 |