دورية أكاديمية
Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol
| العنوان: | Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol |
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| المؤلفون: | Aleksandra Zielińska, Amanda Cano, Tatiana Andreani, Carlos Martins-Gomes, Amélia M. Silva, Marlena Szalata, Ryszard Słomski, Eliana B. Souto |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 11, p 6165 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | lipid-drug conjugates, micelles, cutaneous drug delivery, cannabidiol, lipid nanoparticles, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Lipid nanoparticles are currently used to deliver drugs to specific sites in the body, known as targeted therapy. Conjugates of lipids and drugs to produce drug-enriched phospholipid micelles have been proposed to increase the lipophilic character of drugs to overcome biological barriers. However, their applicability at the topical level is still minimal. Phospholipid micelles are amphiphilic colloidal systems of nanometric dimensions, composed of a lipophilic nucleus and a hydrophilic outer surface. They are currently used successfully as pharmaceutical vehicles for poorly water-soluble drugs. These micelles have high in vitro and in vivo stability and high biocompatibility. This review discusses the use of lipid-drug conjugates as biocompatible carriers for cutaneous application. This work provides a metadata analysis of publications concerning the conjugation of cannabidiol with lipids as a suitable approach and as a new delivery system for this drug. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/11/6165; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23116165 |
| URL الوصول: | https://doaj.org/article/38c556d222a84f10b0779c6cd6f76be1 |
| رقم الأكسشن: | edsdoj.38c556d222a84f10b0779c6cd6f76be1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms23116165 |