دورية أكاديمية
In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil
| العنوان: | In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil |
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| المؤلفون: | André Luís Morais Ruela, Eduardo Costa Figueiredo, Aline Gravinez Perissinato, Ana Carolina Zogbi Lima, Magali Benjamim Araújo, Gislaine Ribeiro Pereira |
| المصدر: | Brazilian Journal of Pharmaceutical Sciences, Vol 49, Iss 3, Pp 579-588 (2013) |
| بيانات النشر: | Universidade de São Paulo, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Nicotina, Adesivos transdérmicos, Célula de difusão vertical, Permeação cutânea, Formulações transdérmicas, Pharmacy and materia medica, RS1-441 |
| الوصف: | The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC). The VDC is an experimental apparatus employed in research, development, and the pharmaceutical field because it can simulate conditions closest to those established in clinical trials. Two transdermal nicotine delivery systems marketed in Brazil to release 14 mg over 24 hours were evaluated. Release studies were carried out using a regenerated cellulose dialysis membrane and permeation studies were carried out using excised porcine ear skin. The results indicated that nicotine release from both evaluated patches follows Higuchi's release kinetics, while skin permeation studies indicated zero-order release kinetics. Nicotine release rates were different between both evaluated patches, but drug permeation rates were not significantly different. According to validation studies, the method was appropriate for evaluating in vitro performance of nicotine patches. The proposed method can be applied to in vitro comparative studies between different commercial nicotine patches and may be used as an auxiliary tool in the design of new transdermal nicotine delivery systems. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2175-9790 1984-8250 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300020&lng=en&tlng=en; https://doaj.org/toc/2175-9790 |
| DOI: | 10.1590/S1984-82502013000300020 |
| URL الوصول: | https://doaj.org/article/aa3930930d0441a791f00de343c4d0fa |
| رقم الأكسشن: | edsdoj.3930930d0441a791f00de343c4d0fa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21759790 19848250 |
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| DOI: | 10.1590/S1984-82502013000300020 |