دورية أكاديمية
Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
| العنوان: | Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases |
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| المؤلفون: | Hao Yu, Patricia Dranchak, Zhiru Li, Ryan MacArthur, Matthew S. Munson, Nurjahan Mehzabeen, Nathan J. Baird, Kevin P. Battalie, David Ross, Scott Lovell, Clotilde K. S. Carlow, Hiroaki Suga, James Inglese |
| المصدر: | Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| بيانات النشر: | Nature Portfolio, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | River blindness, a disease affecting millions throughout the tropics, is caused by parasitic worms. Here, Yuet al. report the discovery and structural characterization of potent macrocyclic peptide inhibitors of iPGM, a nematode-specific phosphoglycerate mutase, as potential leads for novel antimicrobial agents. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 39345025 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/ncomms14932 |
| URL الوصول: | https://doaj.org/article/39345025d3334fe096b7ce4373349fee |
| رقم الأكسشن: | edsdoj.39345025d3334fe096b7ce4373349fee |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20411723 39345025 |
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| DOI: | 10.1038/ncomms14932 |