دورية أكاديمية
Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression
| العنوان: | Single-cell transcriptomic analysis of normal and pathological tissues from the same patient uncovers colon cancer progression |
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| المؤلفون: | Ruifang Sun, Yang Yang, Weidong Lü, Yanqi Yang, Yulong Li, Zhigang Liu, Dongmei Diao, Yang Wang, Su’e Chang, Mengnan Lu, Qiuyu Jiang, Bingling Dai, Xiaobin Ma, Chang’an Zhao, Moqi Lü, Juan Zhang, Caixia Ding, Na Li, Jian Zhang, Zhengtao Xiao, Dangxia Zhou, Chen Huang |
| المصدر: | Cell & Bioscience, Vol 13, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Single cell, Colon adenoma, Colon cancer, Cancer development, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Highlights We performed single-cell transcriptome sequencing in one case carrying adenoma and carcinoma, and explored process of colon cancer progression. Results suggest the presence of dominant clones of same cells including C2 goblet cell, epithelial cell subtype 1 (Epi1), enterocyte cell subset 0 (Entero0), and Entero5 in colon carcinoma We discovered new colon cancer related genes including AC007952.4, NEK8, CHRM3, ANO7, B3GNT6, NEURL1, ODC1 and KCNMA1. The function of TBC1D4, LTB, C2CD4A, AND GBP4/5 in T cells needs to be clarified. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-3701 |
| Relation: | https://doaj.org/toc/2045-3701 |
| DOI: | 10.1186/s13578-023-01002-w |
| URL الوصول: | https://doaj.org/article/3946e8f637bf442681ce84bdbfde0934 |
| رقم الأكسشن: | edsdoj.3946e8f637bf442681ce84bdbfde0934 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20453701 |
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| DOI: | 10.1186/s13578-023-01002-w |