دورية أكاديمية
Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis
| العنوان: | Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis |
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| المؤلفون: | Yanwu Yang, Chenfei Ye, Junyan Sun, Li Liang, Haiyan Lv, Linlin Gao, Jiliang Fang, Ting Ma, Tao Wu |
| المصدر: | NeuroImage: Clinical, Vol 31, Iss , Pp 102715- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | DTI, Parkinson disease, Idiopathic rapid eye movement sleep behaviour disorder, Brain structural network, Multivariate distance matrix regression, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Pinpointing the brain dysconnectivity in idiopathic rapid eye movement sleep behaviour disorder (iRBD) can facilitate preventing the conversion of Parkinson's disease (PD) from prodromal phase. Recent neuroimage investigations reported disruptive brain white matter connectivity in both iRBD and PD, respectively. However, the intrinsic process of the human brain structural network evolving from iRBD to PD still remains largely unknown. To address this issue, 151 participants including iRBD, PD and age-matched normal controls were recruited to receive diffusion MRI scans and neuropsychological examinations. The connectome-wide association analysis was performed to detect reorganization of brain structural network along with PD progression. Eight brain seed regions in both cortical and subcortical areas demonstrated significant structural pattern changes along with the progression of PD. Applying machine learning on the key connectivity related to these seed regions demonstrated better classification accuracy compared to conventional network-based statistic. Our study shows that connectome-wide association analysis reveals the underlying structural connectivity patterns related to the progression of PD, and provide a promising distinct capability to predict prodromal PD patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158221001595; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2021.102715 |
| URL الوصول: | https://doaj.org/article/39869332610044048dd96f9edfc57934 |
| رقم الأكسشن: | edsdoj.39869332610044048dd96f9edfc57934 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2021.102715 |