دورية أكاديمية
أعرض في EDS

Patients with Lower Positive Lymph Nodes Ratio May Benefit from Preoperative Radiotherapy in Stage III Non-Small Cell Lung Cancer

التفاصيل البيبلوغرافية
العنوان: Patients with Lower Positive Lymph Nodes Ratio May Benefit from Preoperative Radiotherapy in Stage III Non-Small Cell Lung Cancer
المؤلفون: Ruiyang Wang MB, Shijie Shang MB, Xinyi Huang MD, Yu Nie MB, Fei Wang PhD, Jinming Yu PhD, MD, Dawei Chen MD
المصدر: Technology in Cancer Research & Treatment, Vol 22 (2023)
بيانات النشر: SAGE Publishing, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Background Although preoperative radiotherapy (PORT) is a promising therapeutic option for stage III non-small cell lung cancer (NSCLC), the efficacy of this treatment remains controversial. The positive lymph node ratio (PLNR) is recognized as an independent prognostic factor for survival. However, no previous studies have focused on the association between PLNR and PORT in stage III NSCLC. Methods Data were collected from the Surveillance, Epidemiology and End Results (SEER) database, and all patients enrolled in this analysis were diagnosed during 2010–2015. The primary endpoint was overall survival (OS). Univariate and multivariate Cox regression analysis was used to identify factors associated with survival before and after case-control matching. PLNR was defined as the ratio of the number of positive lymph nodes to the total number of retrieved or examined lymph nodes. A cutoff value for PLNR was calculated using an X-tile model. Results Overall, 391 patients with PORT and 2814 patients without PORT were enrolled in this study. The cohort after 1:1 case-control matching included 322 patients who received PORT and 322 patients without PORT. PORT was not associated with a significant effect on OS (HR = 1.14; 95% CI: 0.91–1.43; P = 0.825). Multivariate Cox regression analysis showed that PLNR ( P 0.41 who received PORT (HR = 0.59; 95% CI: 0.38–0.91; P = 0.015). Conclusion PLNR may be a prognostic factor for survival in patients with stage III NSCLC who undergo PORT. Lower PLNR is a predictor of better OS and thus warrants further study.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1533-0338
15330338
Relation: https://doaj.org/toc/1533-0338
DOI: 10.1177/15330338231173498
URL الوصول: https://doaj.org/article/39a434208a1141108a37f153c88473c4
رقم الأكسشن: edsdoj.39a434208a1141108a37f153c88473c4
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15330338
DOI:10.1177/15330338231173498