دورية أكاديمية
A novel prognostic model for angioimmunoblastic T-cell lymphoma: A retrospective study of 55 cases
| العنوان: | A novel prognostic model for angioimmunoblastic T-cell lymphoma: A retrospective study of 55 cases |
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| المؤلفون: | Jie Sun, Sha He, Hong Cen, Da Zhou, Zhe Li, Ming-Yue Wang, Qing Ke, Bao-Ping Guo, Cheng-Cheng Liao, Chao Rong, Da-Ni Zhong, Xiao-Hong Tan |
| المصدر: | Journal of International Medical Research, Vol 49 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Objective To explore prognostic factors and develop an accurate prognostic prediction model for angioimmunoblastic T-cell lymphoma (AITL). Methods Clinical data from Chinese patients with newly diagnosed AITL were retrospectively analysed. Overall survival (OS) and progression-free survival (PFS) were estimated using Kaplan-Meier method survival curves; prognostic factors were determined using a Cox proportional hazards model. The sensitivity and specificity of the predicted survival rates were compared using area under the curve (AUC) of receiver operating characteristic (ROC) curves. Results The estimated 5-year OS and PFS of 55 eligible patients with AITL were 22% and 3%, respectively. Multivariate analysis showed that the presence of pneumonia, and serous cavity effusions at initial diagnosis were significant prognostic factors for OS. Based on AUC ROC values, our novel prognostic model was superior to IPI and PIT based models and suggested better diagnostic accuracy. Conclusions Our prognostic model based on pneumonia, and serous cavity effusions at initial diagnosis enabled a balanced classification of AITL patients into different risk groups. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2300 03000605 |
| Relation: | https://doaj.org/toc/1473-2300 |
| DOI: | 10.1177/03000605211013274 |
| URL الوصول: | https://doaj.org/article/ae3a20fa703146108d7b3c48a865fd6e |
| رقم الأكسشن: | edsdoj.3a20fa703146108d7b3c48a865fd6e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14732300 03000605 |
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| DOI: | 10.1177/03000605211013274 |