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The severity of intrahepatic cholestasis during pregnancy increases risks of adverse outcomes beyond stillbirth: evidence from 15,826 patients

التفاصيل البيبلوغرافية
العنوان: The severity of intrahepatic cholestasis during pregnancy increases risks of adverse outcomes beyond stillbirth: evidence from 15,826 patients
المؤلفون: Qiulun Zhou, Yi Yuan, Yuying Wang, Zhuoqi He, Yannei Liang, Suyi Qiu, Yiting Chen, Yiru He, Zi Lv, Huishu Liu
المصدر: BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-9 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Gynecology and obstetrics
مصطلحات موضوعية: Intrahepatic cholestasis during pregnancy, Adverse pregnancy outcomes, Dose-response meta-analysis, Gynecology and obstetrics, RG1-991
الوصف: Abstract Background What kinds of fetal adverse outcomes beyond stillbirth directly correlate to the severity of intrahepatic cholestasis during pregnancy (ICP) remained tangled. Herein, we conducted a retrospective cohort study and a dose-response meta-analysis to speculate the association between the severity of ICP and its adverse outcomes. Methods We retrospectively collected a cohort of ICP patients from electronic records from Guangzhou Women and Children’s Medical Center between Jan 1st, 2018, and Dec 31st, 2022. Also, we searched PubMed, Cochrane, Embase, Scopus, and Web of Science to extract prior studies for meta-analysis. The Kruskal-Wallis test, a one-way or two-way variants analysis (ANOVA), and multi-variant regression are utilized for cohort study. One stage model, restricted cubic spline analysis, and fixed-effect model are applied for dose-response meta-analysis. The data analysis was performed using the R programme. Results Our cohort included 1,289 pregnant individuals, including 385 mild ICP cases, 601 low moderate ICP cases, 282 high moderate ICP cases, and 21 severe ICP cases. The high moderate bile acid levels were correlated to preterm birth [RR = 2.14, 95%CI 1.27 to 3.62), P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2393
Relation: https://doaj.org/toc/1471-2393
DOI: 10.1186/s12884-024-06645-2
URL الوصول: https://doaj.org/article/3a8e04dbaad049c39cad16f4a31a5dd6
رقم الأكسشن: edsdoj.3a8e04dbaad049c39cad16f4a31a5dd6
قاعدة البيانات: Directory of Open Access Journals
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