دورية أكاديمية
Enhancing Bioactive Components of Euryale ferox with Lactobacillus curvatus to Reduce H2O2-Induced Oxidative Stress in Human Skin Fibroblasts
| العنوان: | Enhancing Bioactive Components of Euryale ferox with Lactobacillus curvatus to Reduce H2O2-Induced Oxidative Stress in Human Skin Fibroblasts |
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| المؤلفون: | Yanbing Jiang, Shiquan You, Yongtao Zhang, Jingsha Zhao, Dongdong Wang, Dan Zhao, Meng Li, Changtao Wang |
| المصدر: | Antioxidants, Vol 11, Iss 10, p 1881 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Euryale ferox, Lactobacillus curvatus fermentation, bioactive components, oxidative stress and antiaging, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | This study investigated the effects of Lactobacillus curvatus fermentation on the oxidative stress attenuating effects of Euryale ferox on H2O2-induced human skin fibroblasts (HSF). The results showed that Lactobacillus curvatus fermentation (i) increases the content of the various bioactive components of Euryale ferox and is found to have smaller molecular weights of polysaccharides and polypeptides; (ii) increases the overall intracellular and extracellular antioxidant capacity of H2O2-induced HSF while reducing reactive oxygen species (ROS) levels. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) all showed simultaneous increases in activity. Aside from that, the Nrf2 and MAPK signaling pathways are activated to regulate downstream-associated proteins such as the Bax/Bcl-2 protein ratio, matrix metalloproteinase 1 (MMP-1) activity, and human type I collagen (COL-1). These results suggested that the fermentation of Euryale ferox with Lactobacillus curvatus enhances its antioxidant capacity and attenuates apoptosis and senescence caused by oxidative stress. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11101881 2076-3921 |
| Relation: | https://www.mdpi.com/2076-3921/11/10/1881; https://doaj.org/toc/2076-3921 |
| DOI: | 10.3390/antiox11101881 |
| URL الوصول: | https://doaj.org/article/3acce52a2a204c368a11b56d4c3524c4 |
| رقم الأكسشن: | edsdoj.3acce52a2a204c368a11b56d4c3524c4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11101881 20763921 |
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| DOI: | 10.3390/antiox11101881 |