دورية أكاديمية
Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides
العنوان: | Synthesis, Antimicrobial and Mutagenic Activity of a New Class of d-Xylopyranosides |
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المؤلفون: | Karol Sikora, Piotr Szweda, Karolina Słoczyńska, Justyna Samaszko-Fiertek, Janusz Madaj, Beata Liberek, Elżbieta Pękala, Barbara Dmochowska |
المصدر: | Antibiotics, Vol 12, Iss 5, p 888 (2023) |
بيانات النشر: | MDPI AG, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Therapeutics. Pharmacology |
مصطلحات موضوعية: | d-xylosides, quaternary ammonium salts, NMR, antimicrobial activity, mutagenicity, Therapeutics. Pharmacology, RM1-950 |
الوصف: | Eight N-[2-(2′,3′,4′-tri-O-acetyl-α/β-d-xylopyranosyloxy)ethyl]ammonium bromides, a new class of d-xylopyranosides containing a quaternary ammonium aglycone, were obtained. Their complete structure was confirmed using NMR spectroscopy (1H, 13C, COSY and HSQC) and high-resolution mass spectrometry (HRMS). An antimicrobial activity against fungi (Candida albicans, Candida glabrata) and bacteria (Staphylococcus aureus, Escherichia coli) and a mutagenic Ames test with Salmonella typhimurium TA 98 strain were performed for the obtained compounds. The greatest activity against the tested microorganisms was shown by glycosides with the longest (octyl) hydrocarbon chain in ammonium salt. None of the tested compounds exhibited mutagenic activity in the Ames test. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2079-6382 |
Relation: | https://www.mdpi.com/2079-6382/12/5/888; https://doaj.org/toc/2079-6382 |
DOI: | 10.3390/antibiotics12050888 |
URL الوصول: | https://doaj.org/article/ec3acdc2a4ae457b904b410e7e6c3289 |
رقم الأكسشن: | edsdoj.3acdc2a4ae457b904b410e7e6c3289 |
قاعدة البيانات: | Directory of Open Access Journals |
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