دورية أكاديمية
Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: A case report
| العنوان: | Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: A case report |
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| المؤلفون: | Nicolas M. Orsi, Mini Menon |
| المصدر: | Gynecologic Oncology Reports, Vol 17, Iss C, Pp 83-85 (2016) |
| بيانات النشر: | Elsevier, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Primary ovarian carcinoid tumor, CD56, Synaptophysin, Chromogranin, Ki-67, Diagnostic framework, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Primary ovarian carcinoid tumors are exceptionally rare entities accounting for approximately 0.1% of all ovarian neoplasms. This report describes a primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma in a 65 year-old woman. Macroscopically, the unilateral adnexal tumor was composed of cystic, solid and mucinous elements which resolved into a dual component lesion histologically. The majority of the tumor displayed an organoid architecture with mild to moderate pleomorphism and no discernible mitotic activity, while approximately 10% consisted of sheets and groups of cells with highly pleomorphic nuclei, necrosis and occasional mitoses. Features of a mature cystic teratoma were seen very focally. Immunohistochemistry revealed strong, diffuse positivity for CD56 and synaptophysin. Chromogranin immunonegativity was noted and there was an absence of nuclear β-catenin accumulation. Ki-67 index was 10–12%. Although there is no established diagnostic framework for primary ovarian carcinoid tumors, this case was diagnosed as a well-differentiated neuroendocrine tumor, Grade 2 (intermediate grade), arising in association with a mature cystic teratoma/dermoid cyst. This case highlights the need to develop ovarian diagnostic criteria in this area. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-5789 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352578916300431; https://doaj.org/toc/2352-5789 |
| DOI: | 10.1016/j.gore.2016.07.003 |
| URL الوصول: | https://doaj.org/article/3ace4610182d4063b36af1da30d341ad |
| رقم الأكسشن: | edsdoj.3ace4610182d4063b36af1da30d341ad |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 23525789 |
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| DOI: | 10.1016/j.gore.2016.07.003 |