دورية أكاديمية
DNA methylation of selected tumor suppressor genes in endometrial hyperplasia
| العنوان: | DNA methylation of selected tumor suppressor genes in endometrial hyperplasia |
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| المؤلفون: | Ondrej Dvorak, Munachiso Ndukwe, Marcela Slavickova, Jan Laco, Jiri Spacek |
| المصدر: | Biomedical Papers, Vol 168, Iss 1, Pp 68-73 (2024) |
| بيانات النشر: | Palacký University Olomouc, Faculty of Medicine and Dentistry, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | methylation, cdh13, pten, msh6, endometrial hyperplasia, epigenetics, Medicine |
| الوصف: | Aims. To investigate DNA methylation of specific gene promoters in endometrial hyperplasia compared to normal endometrial tissue. Materials and Methods. To search for epigenetic events, methylation-specific multiplex ligation-dependent probe amplification was employed to compare the methylation status of 64 tissue samples with atypical endometrial hyperplasia, 60 tissue samples with endometrial hyperplasia without atypia, and 40 control tissue samples with normal endometrium. Results. Differences in DNA methylation among the groups were found in PTEN, CDH13, and MSH6 promoters (PTEN: atypical hyperplasia 32%, benign hyperplasia 6.8%, normal endometrium 10%; P=0.004; CDH13: atypical hyperplasia, 50%; benign hyperplasia, 43%; normal endometrium 8.1%; P=0.003; MSH6 atypical hyperplasia 84%, benign hyperplasia, 62%; normal endometrium, 52%; P=0.008.) Higher rates of CDH13 promoter methylation were identified in the groups with both forms of endometrial hyperplasia when compared to the control group (atypical hyperplasia, P=0.003, benign hyperplasia, P=0.0002). A higher rate of DNA methylation of the PTEN and MSH6 promoters was observed in samples with atypical endometrial hyperplasia than in samples with benign endometrial hyperplasia (PTEN: P=0.02; MSH6: P=0.01) and samples with normal endometrial tissue (PTEN, P=0.04; MSH6, P=0.006). Conclusion. DNA methylation of CDH13, PTEN, and MSH6 appear to be involved in the development of endometrial hyperplasia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1213-8118 1804-7521 |
| Relation: | https://biomed.papers.upol.cz/artkey/bio-202401-0009_dna-methylation-of-selected-tumor-suppressor-genes-in-endometrial-hyperplasia.php; https://doaj.org/toc/1213-8118; https://doaj.org/toc/1804-7521 |
| DOI: | 10.5507/bp.2022.053 |
| URL الوصول: | https://doaj.org/article/a3ae070db5d1468d9e96c6b5bfbb7f49 |
| رقم الأكسشن: | edsdoj.3ae070db5d1468d9e96c6b5bfbb7f49 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12138118 18047521 |
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| DOI: | 10.5507/bp.2022.053 |