دورية أكاديمية
Liquid Biopsy, ctDNA Diagnosis through NGS
العنوان: | Liquid Biopsy, ctDNA Diagnosis through NGS |
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المؤلفون: | Chen Lin, Xuzhu Liu, Bingyi Zheng, Rongqin Ke, Chi-Meng Tzeng |
المصدر: | Life, Vol 11, Iss 9, p 890 (2021) |
بيانات النشر: | MDPI AG, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | liquid biopsy, ctDNA, next-generation sequencing, mutation, biomarkers, Science |
الوصف: | Liquid biopsy with circulating tumor DNA (ctDNA) profiling by next-generation sequencing holds great promise to revolutionize clinical oncology. It relies on the basis that ctDNA represents the real-time status of the tumor genome which contains information of genetic alterations. Compared to tissue biopsy, liquid biopsy possesses great advantages such as a less demanding procedure, minimal invasion, ease of frequent sampling, and less sampling bias. Next-generation sequencing (NGS) methods have come to a point that both the cost and performance are suitable for clinical diagnosis. Thus, profiling ctDNA by NGS technologies is becoming more and more popular since it can be applied in the whole process of cancer diagnosis and management. Further developments of liquid biopsy ctDNA testing will be beneficial for cancer patients, paving the way for precision medicine. In conclusion, profiling ctDNA with NGS for cancer diagnosis is both biologically sound and technically convenient. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2075-1729 |
Relation: | https://www.mdpi.com/2075-1729/11/9/890; https://doaj.org/toc/2075-1729 |
DOI: | 10.3390/life11090890 |
URL الوصول: | https://doaj.org/article/3b3795947d4b45219ef6c8691b79ada3 |
رقم الأكسشن: | edsdoj.3b3795947d4b45219ef6c8691b79ada3 |
قاعدة البيانات: | Directory of Open Access Journals |
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