دورية أكاديمية
Downregulation of PPA2 expression correlates with poor prognosis of kidney renal clear cell carcinoma
| العنوان: | Downregulation of PPA2 expression correlates with poor prognosis of kidney renal clear cell carcinoma |
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| المؤلفون: | Wenbiao Zhu, Huiming Jiang, Shoucheng Xie, Huanqin Xiao, Qinghua Liu, Nanhui Chen, Pei Wan, Shanming Lu |
| المصدر: | PeerJ, Vol 9, p e12086 (2021) |
| بيانات النشر: | PeerJ Inc., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Kidney renal clear cell carcinoma, PPA2, Prognosis, Biomarker, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Background Kidney renal clear cell carcinoma (KIRC) is the most common subtype of kidney cancer. Inorganic pyrophosphatase (PPA2) is an enzyme that catalyzes the hydrolysis of pyrophosphate to inorganic phosphate; few studies have reported its significance in cancers. Therefore, we aimed to explore the prognostic value of PPA2 in KIRC. Methods PPA2 expression was detected via immunohistochemistry in a tissue chip containing specimens from 150 patients with KIRC. We evaluated the correlation between PPA2 expression, clinicopathological characteristics, and survival. Data from online databases and another cohort (paraffin-embedded specimens from 10 patients with KIRC) were used for external validation. Results PPA2 expression was significantly lower in KIRC tissues than in normal renal tissues (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| Relation: | https://peerj.com/articles/12086.pdf; https://peerj.com/articles/12086/; https://doaj.org/toc/2167-8359 |
| DOI: | 10.7717/peerj.12086 |
| URL الوصول: | https://doaj.org/article/3b7864162313448c98bfb8839f15ed59 |
| رقم الأكسشن: | edsdoj.3b7864162313448c98bfb8839f15ed59 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.12086 |