دورية أكاديمية
Healthy and Chronic Kidney Disease (CKD) Dogs Have Differences in Serum Metabolomics and Renal Diet May Have Slowed Disease Progression
| العنوان: | Healthy and Chronic Kidney Disease (CKD) Dogs Have Differences in Serum Metabolomics and Renal Diet May Have Slowed Disease Progression |
|---|---|
| المؤلفون: | Marcio Antonio Brunetto, Bruna Ruberti, Doris Pereira Halfen, Douglas Segalla Caragelasco, Thiago Henrique Annibale Vendramini, Vivian Pedrinelli, Henrique Tobaro Macedo, Juliana Toloi Jeremias, Cristiana Fonseca Ferreira Pontieri, Fernanda Maria Marins Ocampos, Luis Alberto Colnago, Marcia Mery Kogika |
| المصدر: | Metabolites, Vol 11, Iss 11, p 782 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Microbiology |
| مصطلحات موضوعية: | renal dogs, uremic toxins, metabolic profile, nutrition, survival, Microbiology, QR1-502 |
| الوصف: | Chronic kidney disease (CKD) is highly prevalent in dogs, and metabolomics investigation has been recently introduced for a better understanding of the role of diet in CKD. This study aimed to compare the serum metabolomic profile of healthy dogs (CG) and dogs with CKD (CKD-T0 and CKD-T6) to evaluate whether the diet would affect metabolites. Six dogs (5 females; 1 male; 7.47 ± 2.31 years old) with CKD stage 3 or 4 (IRIS) were included. CG consisted of 10 healthy female dogs (5.89 ± 2.57 years old) fed a maintenance diet. Serum metabolites were analyzed by 1H nuclear magnetic resonance (1H NMR) spectra. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to assess differences in metabolomic profiles between groups and before (CKD-T0) and after renal diet (CKD-T6). Data analysis was performed on SIMCA-P software. Dogs with CKD showed an altered metabolic profile with increased urea, creatinine, creatine, citrate, and lipids. Lactate, branched-chain amino acids (BCAAs), and glutamine were decreased in the CKD group. However, after 6 months of diet, the metabolite profiles of CKD-T0 and CKD-T6 were similar. Metabolomics profile may be useful to evaluate and recognize metabolic dysfunction and progression of CKD, and the diet may have helped maintain and retard the progression of CKD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2218-1989 |
| Relation: | https://www.mdpi.com/2218-1989/11/11/782; https://doaj.org/toc/2218-1989 |
| DOI: | 10.3390/metabo11110782 |
| URL الوصول: | https://doaj.org/article/3b7f67872b454be5b0b7a22e079a8e05 |
| رقم الأكسشن: | edsdoj.3b7f67872b454be5b0b7a22e079a8e05 |
| قاعدة البيانات: | Directory of Open Access Journals |
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