دورية أكاديمية
Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccinationResearch in context
| العنوان: | Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccinationResearch in context |
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| المؤلفون: | Clara Duran-Castells, Anna Prats, Bruna Oriol-Tordera, Anuska Llano, Cristina Galvez, Javier Martinez-Picado, Ester Ballana, Edurne Garcia-Vidal, Bonaventura Clotet, Jose A. Muñoz-Moreno, Thomas Hanke, José Moltó, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol |
| المصدر: | EBioMedicine, Vol 95, Iss , Pp 104732- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | Control of HIV-1 infection, Plasma proteomics, Inflammation, Neurological function, Siglec-3/CD33, Kick and kill HIV cure strategy, Medicine, Medicine (General), R5-920 |
| الوصف: | Summary: Background: Biomarkers predicting the outcome of HIV-1 virus control in natural infection and after therapeutic interventions in HIV-1 cure trials remain poorly defined. The BCN02 trial (NCT02616874), combined a T-cell vaccine with romidepsin (RMD), a cancer-drug that was used to promote HIV-1 latency reversal and which has also been shown to have beneficial effects on neurofunction. We conducted longitudinal plasma proteomics analyses in trial participants to define biomarkers associated with virus control during monitored antiretroviral pause (MAP) and to identify novel therapeutic targets that can improve future cure strategies. Methods: BCN02 was a phase I, open-label, single-arm clinical trial in early-treated, HIV infected individuals. Longitudinal plasma proteomes were analyzed in 11 BCN02 participants, including 8 participants that showed a rapid HIV-1 plasma rebound during a monitored antiretroviral pause (MAP-NC, ‘non-controllers’) and 3 that remained off ART with sustained plasma viremia |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396423002979; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2023.104732 |
| URL الوصول: | https://doaj.org/article/3b80065fccfc4b748f1b0fc22a58d62a |
| رقم الأكسشن: | edsdoj.3b80065fccfc4b748f1b0fc22a58d62a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2023.104732 |