دورية أكاديمية
Targeted cortical reorganization using optogenetics in non-human primates
| العنوان: | Targeted cortical reorganization using optogenetics in non-human primates |
|---|---|
| المؤلفون: | Azadeh Yazdan-Shahmorad, Daniel B Silversmith, Viktor Kharazia, Philip N Sabes |
| المصدر: | eLife, Vol 7 (2018) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | optogenetics, non-human primates, neuromodulation, plasticity, neural stimulation, functional connectivity, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in two macaques. A large-scale optogenetic interface enabled simultaneous stimulation of excitatory neurons and electrocorticographic recording across primary somatosensory (S1) and motor (M1) cortex (Yazdan-Shahmorad et al., 2016). We tracked two measures of network connectivity, the network response to focal stimulation and the baseline coherence between pairs of electrodes; these were strongly correlated before stimulation. Within minutes, stimulation in S1 or M1 significantly strengthened the gross functional connectivity between these areas. At a finer scale, stimulation led to heterogeneous connectivity changes across the network. These changes reflected the correlations introduced by stimulation-evoked activity, consistent with Hebbian plasticity models. This work extends Hebbian plasticity models to large-scale circuits, with significant implications for stimulation-based neurorehabilitation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/31034; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.31034 |
| URL الوصول: | https://doaj.org/article/3d174b4951b14efba5702b3dce0bc5ce |
| رقم الأكسشن: | edsdoj.3d174b4951b14efba5702b3dce0bc5ce |
| قاعدة البيانات: | Directory of Open Access Journals |
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