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Drug delivery strategy in hepatocellular carcinoma therapy

التفاصيل البيبلوغرافية
العنوان: Drug delivery strategy in hepatocellular carcinoma therapy
المؤلفون: Sisi Yang, Chengwei Cai, Huanqiu Wang, Xueqing Ma, Anwen Shao, Jifang Sheng, Chengbo Yu
المصدر: Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Cytology
مصطلحات موضوعية: Hepatocellular carcinoma, Nanoparticle, Drug delivery, Tumor microenvironment, Medicine, Cytology, QH573-671
الوصف: Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with high rates of recurrence and death. Surgical resection and ablation therapy have limited efficacy for patients with advanced HCC and poor liver function, so pharmacotherapy is the first-line option for those patients. Traditional antitumor drugs have the disadvantages of poor biological distribution and pharmacokinetics, poor target selectivity, high resistance, and high toxicity to nontargeted tissues. Recently, the development of nanotechnology has significantly improved drug delivery to tumor sites by changing the physical and biological characteristics of drugs and nanocarriers to improve their pharmacokinetics and biological distribution and to selectively accumulate cytotoxic agents at tumor sites. Here, we systematically review the tumor microenvironment of HCC and the recent application of nanotechnology in HCC. Video Abstract.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1478-811X
Relation: https://doaj.org/toc/1478-811X
DOI: 10.1186/s12964-021-00796-x
URL الوصول: https://doaj.org/article/e3dc1aa16db542d9864ec8567bc1339d
رقم الأكسشن: edsdoj.3dc1aa16db542d9864ec8567bc1339d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1478811X
DOI:10.1186/s12964-021-00796-x