دورية أكاديمية
Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields
| العنوان: | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields |
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| المؤلفون: | Yong Jun Choi, Min Jae Lee, Min Kwang Byun, Sangho Park, Jimyung Park, Dongil Park, Sang-Hoon Kim, Youngsam Kim, Seong Yong Lim, Kwang Ha Yoo, Ki Suck Jung, Hye Jung Park |
| المصدر: | Tuberculosis and Respiratory Diseases, Vol 87, Iss 1, Pp 65-79 (2024) |
| بيانات النشر: | The Korean Academy of Tuberculosis and Respiratory Diseases, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | exhaled condensates, chronic obstructive pulmonary disease, lung function test, eosinophils, Diseases of the respiratory system, RC705-779 |
| الوصف: | Background Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of six and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strong positive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specific version of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725, p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078, p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forced expiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significant correlation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1 alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin (ρ=0.4445 and p=0.0017). Conclusion Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1738-3536 2005-6184 |
| Relation: | http://e-trd.org/upload/pdf/trd-2023-0028.pdf; https://doaj.org/toc/1738-3536; https://doaj.org/toc/2005-6184 |
| DOI: | 10.4046/trd.2023.0028 |
| URL الوصول: | https://doaj.org/article/3ecc31af117749cfbdfa255803fde284 |
| رقم الأكسشن: | edsdoj.3ecc31af117749cfbdfa255803fde284 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17383536 20056184 |
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| DOI: | 10.4046/trd.2023.0028 |