دورية أكاديمية
Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 1; peer review: 2 approved]
| العنوان: | Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 1; peer review: 2 approved] |
|---|---|
| المؤلفون: | Filip Mundt, Sebastian Porsdam Mann, Nicolai J. Wewer Albrechtsen, Medini Ghodgaonkar-Steger, Peter Treit, Reinout Raijmakers, Martina O’Flaherty, Albert J.R. Heck, Juan Antonio Vizcaíno, Matthias Mann |
| المصدر: | Open Research Europe, Vol 3 (2023) |
| بيانات النشر: | F1000 Research Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science LCC:Social Sciences |
| مصطلحات موضوعية: | Clinical proteomics, clinical research, ethical challenges, eng, Science, Social Sciences |
| الوصف: | With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved drugs currently target proteins, and most diagnostic tests are protein-based. The introduction of proteomics to the clinic, for instance to guide patient stratification and treatment, is already ongoing. Importantly, ethical challenges come with this success, which must also be adequately addressed by the proteomics and medical communities. Consortium members of the H2020 European Union-funded proteomics initiative: European Proteomics Infrastructure Consortium-providing access (EPIC-XS) met at the Core Technologies for Life Sciences (CTLS) conference to discuss the emerging role and implementation of proteomics in the clinic. The discussion, involving leaders in the field, focused on the current status, related challenges, and future efforts required to make proteomics a more mainstream technology for translational and clinical research. Here we report on that discussion and provide an expert update concerning the feasibility of clinical proteomics, the ethical implications of generating and analyzing large-scale proteomics clinical data, and recommendations to ensure both ethical and effective implementation in real-world applications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2732-5121 |
| Relation: | https://open-research-europe.ec.europa.eu/articles/3-59/v1; https://doaj.org/toc/2732-5121 |
| DOI: | 10.12688/openreseurope.15810.1 |
| URL الوصول: | https://doaj.org/article/414f3e7d31fd4a8d8506e4105d106b7a |
| رقم الأكسشن: | edsdoj.414f3e7d31fd4a8d8506e4105d106b7a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27325121 |
|---|---|
| DOI: | 10.12688/openreseurope.15810.1 |