دورية أكاديمية
Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers
| العنوان: | Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers |
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| المؤلفون: | Jaeseung Song, Daeun Kim, Juyeon Hong, Go Woon Kim, Junghyun Jung, Sejin Park, Hee Jung Park, Jong Wha J. Joo, Wonhee Jang |
| المصدر: | Genes, Vol 10, Iss 11, p 864 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | polymyositis, dermatomyositis, meta-analysis, multiple-phenotype analysis, Genetics, QH426-470 |
| الوصف: | Polymyositis (PM) and dermatomyositis (DM) are both classified as idiopathic inflammatory myopathies. They share a few common characteristics such as inflammation and muscle weakness. Previous studies have indicated that these diseases present aspects of an auto-immune disorder; however, their exact pathogenesis is still unclear. In this study, three gene expression datasets (PM: 7, DM: 50, Control: 13) available in public databases were used to conduct meta-analysis. We then conducted expression quantitative trait loci analysis to detect the variant sites that may contribute to the pathogenesis of PM and DM. Six-hundred differentially expressed genes were identified in the meta-analysis (false discovery rate (FDR) < 0.01), among which 317 genes were up-regulated and 283 were down-regulated in the disease group compared with those in the healthy control group. The up-regulated genes were significantly enriched in interferon-signaling pathways in protein secretion, and/or in unfolded-protein response. We detected 10 single nucleotide polymorphisms (SNPs) which could potentially play key roles in driving the PM and DM. Along with previously reported genes, we identified 4 novel genes and 10 SNP-variant regions which could be used as candidates for potential drug targets or biomarkers for PM and DM. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2073-4425 80108644 |
| Relation: | https://www.mdpi.com/2073-4425/10/11/864; https://doaj.org/toc/2073-4425 |
| DOI: | 10.3390/genes10110864 |
| URL الوصول: | https://doaj.org/article/41956d801086449c99386a3b9253848e |
| رقم الأكسشن: | edsdoj.41956d801086449c99386a3b9253848e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20734425 80108644 |
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| DOI: | 10.3390/genes10110864 |