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IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES

التفاصيل البيبلوغرافية
العنوان: IMMUNOSUPPRESSIVE EFFECTS OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES
المؤلفون: E. A. Starikova, A. V. Sokolov, L. A. Burova, I. S. Freidlin
المصدر: Медицинская иммунология, Vol 17, Iss 4, Pp 303-318 (2015)
بيانات النشر: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, 2015.
سنة النشر: 2015
المجموعة: LCC:Immunologic diseases. Allergy
مصطلحات موضوعية: arginine deiminase, streptococcus pyogenes, immunosuppression, Immunologic diseases. Allergy, RC581-607
الوصف: Many pathogens use metabolic pathway of arginine for successful dissemination. Bacterial arginine deiminase hydrolyzes arginine to form one molecule of ammonia and two molecules of ATP. The activity of the enzyme contributes to the improvement of survival of pathogenic bacteria in conditions of low pH at the site of infection or in phagolysosome, as well as in anaerobic conditions, and also leads to deficiency of arginine. Metabolism of arginine plays an important role in regulating the functions of immune system cells in mammals. Arginine is a substrate of enzymes NOS and arginase. Arginine depletion, potentially contributs to immunosuppression. The review analyzed the literature data on the effect of streptococcal arginine deiminase on the metabolism of arginine eukaryotic cells, and discusses immunosuppressive action of the enzyme.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: Russian
تدمد: 1563-0625
2313-741X
Relation: https://www.mimmun.ru/mimmun/article/view/922; https://doaj.org/toc/1563-0625; https://doaj.org/toc/2313-741X
DOI: 10.15789/1563-0625-2015-4-303-318
URL الوصول: https://doaj.org/article/44e07b72652e4e4a824a251de0ea5a3c
رقم الأكسشن: edsdoj.44e07b72652e4e4a824a251de0ea5a3c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15630625
2313741X
DOI:10.15789/1563-0625-2015-4-303-318