التفاصيل البيبلوغرافية
العنوان:
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
المؤلفون:
Emilie Crouchet , Simonetta Bandiera , Naoto Fujiwara , Shen Li , Hussein El Saghire , Mirian Fernández-Vaquero , Tobias Riedl , Xiaochen Sun , Hadassa Hirschfield , Frank Jühling , Shijia Zhu , Natascha Roehlen , Clara Ponsolles , Laura Heydmann , Antonio Saviano , Tongqi Qian , Anu Venkatesh , Joachim Lupberger , Eloi R. Verrier , Mozhdeh Sojoodi , Marine A. Oudot , François H. T. Duong , Ricard Masia , Lan Wei , Christine Thumann , Sarah C. Durand , Victor González-Motos , Danijela Heide , Jenny Hetzer , Shigeki Nakagawa , Atsushi Ono , Won-Min Song , Takaaki Higashi , Roberto Sanchez , Rosa S. Kim , C. Billie Bian , Karun Kiani , Tom Croonenborghs , Aravind Subramanian , Raymond T. Chung , Beate K. Straub , Detlef Schuppan , Maliki Ankavay , Laurence Cocquerel , Evelyne Schaeffer , Nicolas Goossens , Anna P. Koh , Milind Mahajan , Venugopalan D. Nair , Ganesh Gunasekaran , Myron E. Schwartz , Nabeel Bardeesy , Alex K. Shalek , Orit Rozenblatt-Rosen , Aviv Regev , Emanuele Felli , Patrick Pessaux , Kenneth K. Tanabe , Mathias Heikenwälder , Catherine Schuster , Nathalie Pochet , Mirjam B. Zeisel , Bryan C. Fuchs , Yujin Hoshida , Thomas F. Baumert
المصدر:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
بيانات النشر:
Nature Portfolio, 2021.
سنة النشر:
2021
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors present a human liver cell-based system modeling a clinical prognostic signature allowing to propose nizatidine for treatment of advanced liver fibrosis and hepatocellular carcinoma prevention.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/s41467-021-25468-9
URL الوصول:
https://doaj.org/article/454d7d31ae1e40b7812cd73b90a2e7e3
رقم الأكسشن:
edsdoj.454d7d31ae1e40b7812cd73b90a2e7e3
قاعدة البيانات:
Directory of Open Access Journals
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