دورية أكاديمية
Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery
العنوان: | Development of Novel Faster-Dissolving Microneedle Patches for Transcutaneous Vaccine Delivery |
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المؤلفون: | Akihiko Ono, Sayami Ito, Shun Sakagami, Hideo Asada, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Sachiko Hirobe, Naoki Okada |
المصدر: | Pharmaceutics, Vol 9, Iss 3, p 27 (2017) |
بيانات النشر: | MDPI AG, 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Pharmacy and materia medica |
مصطلحات موضوعية: | transcutaneous vaccine, faster-dissolving microneedle, carboxymethylcellulose, hyaluronan, clinical research, microneedle-dissolution kinetics in the skin, microneedle failure force, Pharmacy and materia medica, RS1-441 |
الوصف: | Microneedle (MN) patches are promising for transcutaneous vaccination because they enable vaccine antigens to physically penetrate the stratum corneum via low-invasive skin puncturing, and to be effectively delivered to antigen-presenting cells in the skin. In second-generation MN patches, the dissolving MNs release the loaded vaccine antigen into the skin. To shorten skin application time for clinical practice, this study aims to develop novel faster-dissolving MNs. We designed two types of MNs made from a single thickening agent, carboxymethylcellulose (CMC) or hyaluronan (HN). Both CMC-MN and HN-MN completely dissolved in rat skin after a 5-min application. In pre-clinical studies, both MNs could demonstrably increase antigen-specific IgG levels after vaccination and prolong antigen deposition compared with conventional injections, and deliver antigens into resected human dermal tissue. In clinical research, we demonstrated that both MNs could reliably and safely puncture human skin without any significant skin irritation from transepidermal water loss measurements and ICDRG (International Contact Dermatitis Research Group) evaluation results. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1999-4923 |
Relation: | https://www.mdpi.com/1999-4923/9/3/27; https://doaj.org/toc/1999-4923 |
DOI: | 10.3390/pharmaceutics9030027 |
URL الوصول: | https://doaj.org/article/d4578944afb640dba6b18fb42493c65d |
رقم الأكسشن: | edsdoj.4578944afb640dba6b18fb42493c65d |
قاعدة البيانات: | Directory of Open Access Journals |
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