دورية أكاديمية
The Effect of Dental Stem Cell Conditioned Medium on the Thickness of the Damaged Retina in Rat
| العنوان: | The Effect of Dental Stem Cell Conditioned Medium on the Thickness of the Damaged Retina in Rat |
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| المؤلفون: | Alireza Dehghani, Mohammad Malekahmadi, Fereshteh Karamali, Sareh Soroushzadeh, Heshmatollah Ghanbari, Ardeshir Talebi, Mohammad Hossein Nasr Esfahani |
| المصدر: | مجله دانشکده پزشکی اصفهان, Vol 40, Iss 668, Pp 256-261 (2022) |
| بيانات النشر: | Isfahan University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | dental papilla, retina, stem cells, hydrogen peroxide, conditioned medium, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Mesenchymal stem cells and their secretions contain various factors that have anti-inflammatory properties. The aim of this study was to evaluate the effect of environment derived from stem cell from apical papilla (SCAP) on H2O2-induced retinal toxicity in rats.Methods: Twenty healthy rats were selected for this study, all of which underwent intravitreal H2O2 injection in days 1 and 2 of the right eye. They were then randomly divided into two groups: no other intervention was performed in the first group, but in the second group, on the fifth day, the conditioned medium adjacent to the stem cell of apex of the dental papilla were injected into the vitreous of the right eye. The left eye was considered as the control. After two weeks, all rats were euthanized and histological evaluation was performed.Findings: Retinal thickness in the second group (236.8 ± 20.8 microns) was closer to the control group compared to the first group (199.9 ± 65.3 microns) which was statistically significant.Conclusion: This study showed that the Conditioned medium adjacent to SCAP contains secretory factors that can have a protective effect on damaged retinal cells and reduce the rate of retinal atrophy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 1027-7595 1735-854X |
| Relation: | https://jims.mui.ac.ir/article_24271_1d24f8e39a7b54035ec3e0d548f4fcf9.pdf; https://doaj.org/toc/1027-7595; https://doaj.org/toc/1735-854X |
| DOI: | 10.48305/jims.v40.i668.0256 |
| URL الوصول: | https://doaj.org/article/459b205824584997bf96e0044cc48765 |
| رقم الأكسشن: | edsdoj.459b205824584997bf96e0044cc48765 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10277595 1735854X |
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| DOI: | 10.48305/jims.v40.i668.0256 |