دورية أكاديمية
Comprehensive analysis of the clinical significance, immune infiltration, and biological role of MARCH ligases in HCC
العنوان: | Comprehensive analysis of the clinical significance, immune infiltration, and biological role of MARCH ligases in HCC |
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المؤلفون: | Jun Cao, Dao-yuan Tu, Jie Zhou, Guo-qing Jiang, Sheng-jie Jin, Bing-bing Su, Hao Tang, Yu-hong Tang, Ao-qing Wang, Qian Wang, Ren-jie Liu, Chi Zhang, Dou-sheng Bai |
المصدر: | Frontiers in Immunology, Vol 13 (2022) |
بيانات النشر: | Frontiers Media S.A., 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Immunologic diseases. Allergy |
مصطلحات موضوعية: | MARCH ligases, tumor immune microenvironment, prognostic signature, bioinformatics, hepatocellular carcinoma, Immunologic diseases. Allergy, RC581-607 |
الوصف: | The membrane‐associated RING‐CH (MARCH) family, a member of the E3 ubiquitin ligases, has been confirmed by a growing number of studies to be associated with immune function and has been highlighted as a potential immunotherapy target. In our research, hepatocellular carcinoma (HCC) patients were divided into C1 and C2 MARCH ligase-related patterns by the non-negative matrix factorization (NMF) algorithm. Multiple analyses revealed that the MARCH ligase-related cluster was related to prognosis, clinicopathological characteristics, and the tumor immune microenvironment (TIME). Next, the signature (risk score) of the MARCH prognosis was constructed, including eight genes associated with the MARCH ligase (CYP2C9, G6PD, SLC1A5, SPP1, ANXA10, CDC20, PON1, and FTCD). The risk score showed accuracy and stability. We found that the correlations between risk score and TIME, tumor mutation burden (TMB), prognosis, and clinicopathological characteristics were significant. Additionally, the risk score also had important guiding significance for HCC treatment, including chemotherapy, immunotherapy, and transarterial chemoembolization (TACE). |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-3224 |
Relation: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.997265/full; https://doaj.org/toc/1664-3224 |
DOI: | 10.3389/fimmu.2022.997265 |
URL الوصول: | https://doaj.org/article/45f8600002524d45a8a1dc922829dec4 |
رقم الأكسشن: | edsdoj.45f8600002524d45a8a1dc922829dec4 |
قاعدة البيانات: | Directory of Open Access Journals |
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