دورية أكاديمية
أعرض في EDS

Genome-wide analysis of circular RNAs and validation of hsa_circ_0086354 as a promising biomarker for early diagnosis of cerebral palsy

التفاصيل البيبلوغرافية
العنوان: Genome-wide analysis of circular RNAs and validation of hsa_circ_0086354 as a promising biomarker for early diagnosis of cerebral palsy
المؤلفون: Yuanyuan Hu, Xuzhao Bian, Chao Wu, Yan Wang, Yang Wu, Xiaoqin Gu, Suyan Zhuo, Shiquan Sun
المصدر: BMC Medical Genomics, Vol 15, Iss 1, Pp 1-9 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Internal medicine
LCC:Genetics
مصطلحات موضوعية: Cerebral palsy diagnosis, Biomarker, hsa_circ_0086354, Internal medicine, RC31-1245, Genetics, QH426-470
الوصف: Abstract Background Cerebral palsy (CP) is a spectrum of non-progressive motor disorders caused by brain injury during fetal or postnatal periods. Current diagnosis of CP mainly relies on neuroimaging and motor assessment. Here, we aimed to explore novel biomarkers for early diagnosis of CP. Methods Blood plasma from five children with CP and their healthy twin brothers/sisters was analyzed by gene microarray to screen out differentially expressed RNAs. Selected differentially expressed circular RNAs (circRNAs) were further validated using quantitative real-time PCR. Receiver operating characteristic (ROC) curve analysis was used to assess the specificity and sensitivity of hsa_circ_0086354 in discriminating children with CP and healthy controls. Results 43 up-regulated circRNAs and 2 down-regulated circRNAs were obtained by difference analysis (fold change > 2, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1755-8794
Relation: https://doaj.org/toc/1755-8794
DOI: 10.1186/s12920-022-01163-6
URL الوصول: https://doaj.org/article/465703d7316b46ab8c27be17e85bf04f
رقم الأكسشن: edsdoj.465703d7316b46ab8c27be17e85bf04f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17558794
DOI:10.1186/s12920-022-01163-6