دورية أكاديمية
Ethanol consumption in non-human primates alters plasma markers of bone turnover but not tibia architecture
| العنوان: | Ethanol consumption in non-human primates alters plasma markers of bone turnover but not tibia architecture |
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| المؤلفون: | Alibek Zhakubayev, Lara H. Sattgast, Anne D. Lewis, Kathleen A. Grant, Russell T. Turner, Urszula T. Iwaniec, Mary Lauren Benton |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Bone architecture, Ethanol, Non-human primate, Medicine, Science |
| الوصف: | Abstract Ethanol consumption is associated with positive, negative, and neutral effects on the skeletal system. Our previous work using a nonhuman primate model of voluntary ethanol consumption showed that chronic ethanol use has an impact on skeletal attributes, most notably on biochemical markers of bone turnover. However, these studies were limited by small sample sizes and resulting lack of statistical power. Here, we applied a machine learning framework to integrate data from 155 monkeys (100 ethanol and 55 controls) to identify the bone features associated with chronic ethanol use. Specifically, we analyzed the influence of ethanol consumption on biomarkers of bone turnover and cancellous and cortical bone architecture in tibia. We hypothesized that chronic ethanol use for 6 months to 2.5 years would result in measurable changes to cancellous features and the biochemical markers compared to control animals. We observed a decrease in bone turnover in monkeys exposed to ethanol; however, we did not find that ethanol consumption resulted in measurable changes in bone architecture. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-65021-4 |
| URL الوصول: | https://doaj.org/article/4884a25d7cce44a6985009b94c79cc71 |
| رقم الأكسشن: | edsdoj.4884a25d7cce44a6985009b94c79cc71 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-65021-4 |