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Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome.

التفاصيل البيبلوغرافية
العنوان: Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome.
المؤلفون: Christopher H Gibbons, Istvan Bonyhay, Adam Benson, Ningshan Wang, Roy Freeman
المصدر: PLoS ONE, Vol 8, Iss 12, p e84716 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: To define the neuropathology, clinical phenotype, autonomic physiology and differentiating features in individuals with neuropathic and non-neuropathic postural tachycardia syndrome (POTS).Twenty-four subjects with POTS and 10 healthy control subjects had skin biopsy analysis of intra-epidermal nerve fiber density (IENFD), quantitative sensory testing (QST) and autonomic testing. Subjects completed quality of life, fatigue and disability questionnaires. Subjects were divided into neuropathic and non-neuropathic POTS, defined by abnormal IENFD and abnormal small fiber and sudomotor function.Nine of 24 subjects had neuropathic POTS and had significantly lower resting and tilted heart rates; reduced parasympathetic function; and lower phase 4 valsalva maneuver overshoot compared with those with non-neuropathic POTS (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3874039?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0084716
URL الوصول: https://doaj.org/article/e4a3c5bb7935448c913965b4edffa788
رقم الأكسشن: edsdoj.4a3c5bb7935448c913965b4edffa788
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0084716