دورية أكاديمية
Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances
| العنوان: | Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances |
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| المؤلفون: | Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang |
| المصدر: | Annals of Medicine, Vol 55, Iss 1, Pp 973-989 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | lncRNAs, circRNAs, ceRNA, rheumatoid arthritis, molecular mechanisms, therapeutic implications, Medicine |
| الوصف: | AbstractRheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration. Abnormal expression or function of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are closely related to human diseases, including RA. There has been increasing evidence showing that in the competitive endogenous RNA (ceRNA) networks, both lncRNA and circRNA are vital in the biological functions of cells. Nevertheless, the exact mechanism of ceRNA in RA remains to be investigated. Herein, we summarized the molecular potencies of lncRNA/circRNA-mediated ceRNA networks in RA, with emphasis on the phenotypic regulation of ceRNA in the progression of RA, including regulation of proliferation, invasion, inflammation and apoptosis, as well as the role of ceRNA in traditional Chinese medicine (TCM) in the treatment of RA. In addition, we also discussed the future direction and potential clinical value of ceRNA in the treatment of RA, which may provide potential reference value for clinical trials of TCM therapy for the treatment of RA.Key messagesLong noncoding RNA/circular RNA can work as the competitive endogenous RNA sponge and participate in the pathogenesis of rheumatoid arthritis.Traditional Chinese medicine and its agents have shown potential roles in the prevention and treatment of rheumatoid arthritis via competitive endogenous RNA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 07853890 1365-2060 0785-3890 |
| Relation: | https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060 |
| DOI: | 10.1080/07853890.2023.2172605 |
| URL الوصول: | https://doaj.org/article/4b92b730f4b1438fb79e89f2526686a6 |
| رقم الأكسشن: | edsdoj.4b92b730f4b1438fb79e89f2526686a6 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 07853890 13652060 |
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| DOI: | 10.1080/07853890.2023.2172605 |