دورية أكاديمية
Cumulative live birth rates do not increase after 4 complete cycles in women with poor ovarian response: a retrospective study of 1,825 patients
| العنوان: | Cumulative live birth rates do not increase after 4 complete cycles in women with poor ovarian response: a retrospective study of 1,825 patients |
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| المؤلفون: | Meng Wang, M.D., Lei Jia, M.S., Xiao-Lan Li, M.D., Jia-Yi Guo, B.S., Cong Fang, Ph.D., Rui Huang, Ph.D., Xiao-Yan Liang, Ph.D. |
| المصدر: | F&S Reports, Vol 2, Iss 2, Pp 201-208 (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | Controlled ovarian stimulation protocols, cumulative clinical pregnancy rates, cumulative live birth rates, poor ovarian response, Diseases of the genitourinary system. Urology, RC870-923, Gynecology and obstetrics, RG1-991 |
| الوصف: | Objective: To investigate whether the cumulative clinical pregnancy rates (CCPR) and cumulative live birth rates (CLBR) increase as the oocyte retrieval cycle increases in women with poor ovarian response. Design: Retrospective cohort study. Setting: Not applicable. Patient(s): Women diagnosed of poor ovarian response (POR) according to the Bologna criteria and who completed in vitro fertilization or intracytoplasmic sperm injection cycles between January 2014 and December 2018. Intervention(s): Not applicable. Main Outcome Measure(s): The conservative and optimistic estimations of CCPR and CLBR. Result(s): The conservative and optimistic estimates of CCPR peaked at the 6th complete cycle, reaching 36.44% and 71.61%, respectively. However, the conservative and optimistic estimates of CLBR peaked at the 4th complete cycle, reaching 20.22% and 38.31%, respectively. The live birth rate per complete cycle of mild stimulation protocol was comparable to other protocols after adjusting for the confounding factors. For patients ≤35 years, the live birth rate per complete cycle of progestin-primed ovarian stimulation (adjusted odds ratio = 0.51, 95% confidence interval: 0.30–0.87) and gonadotropin-releasing hormone antagonist protocol (adjusted odds ratio=0.45, 95% confidence interval: 0.24–0.81) were significantly lower than that of the mild stimulation. Conclusion(s): It is not advisable to initiate more than four complete cycles for POR patients since CLBR do not increase after that. For POR patients ≤35 years, the live birth rate per complete cycle increased in women with mild stimulation protocol. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-3341 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666334121000040; https://doaj.org/toc/2666-3341 |
| DOI: | 10.1016/j.xfre.2021.01.004 |
| URL الوصول: | https://doaj.org/article/5038517fbd5f4efe8553e3d5ac374d34 |
| رقم الأكسشن: | edsdoj.5038517fbd5f4efe8553e3d5ac374d34 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 26663341 |
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| DOI: | 10.1016/j.xfre.2021.01.004 |