دورية أكاديمية
Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia
| العنوان: | Combining fMRI and DISC1 gene haplotypes to understand working memory-related brain activity in schizophrenia |
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| المؤلفون: | Maria Guardiola-Ripoll, Alejandro Sotero-Moreno, Carmen Almodóvar-Payá, Noemí Hostalet, Amalia Guerrero-Pedraza, Núria Ramiro, Jordi Ortiz-Gil, Bárbara Arias, Mercè Madre, Joan Soler-Vidal, Raymond Salvador, Peter J. McKenna, Edith Pomarol-Clotet, Mar Fatjó-Vilas |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract The DISC1 gene is one of the most relevant susceptibility genes for psychosis. However, the complex genetic landscape of this locus, which includes protective and risk variants in interaction, may have hindered consistent conclusions on how DISC1 contributes to schizophrenia (SZ) liability. Analysis from haplotype approaches and brain-based phenotypes can contribute to understanding DISC1 role in the neurobiology of this disorder. We assessed the brain correlates of DISC1 haplotypes associated with SZ through a functional neuroimaging genetics approach. First, we tested the association of two DISC1 haplotypes, the HEP1 (rs6675281-1000731-rs999710) and the HEP3 (rs151229-rs3738401), with the risk for SZ in a sample of 138 healthy subjects (HS) and 238 patients. This approach allowed the identification of three haplotypes associated with SZ (HEP1-CTG, HEP3-GA and HEP3-AA). Second, we explored whether these haplotypes exerted differential effects on n-back associated brain activity in a subsample of 70 HS compared to 70 patients (diagnosis × haplotype interaction effect). These analyses evidenced that HEP3-GA and HEP3-AA modulated working memory functional response conditional to the health/disease status in the cuneus, precuneus, middle cingulate cortex and the ventrolateral and dorsolateral prefrontal cortices. Our results are the first to show a diagnosis-based effect of DISC1 haplotypes on working memory-related brain activity, emphasising its role in SZ. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-10660-8 |
| URL الوصول: | https://doaj.org/article/516f15b0aae94c4cafb989237b8f06ef |
| رقم الأكسشن: | edsdoj.516f15b0aae94c4cafb989237b8f06ef |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-10660-8 |