دورية أكاديمية
Next-generation sequencing revealed synchronous double primary lung squamous carcinoma: a case report
| العنوان: | Next-generation sequencing revealed synchronous double primary lung squamous carcinoma: a case report |
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| المؤلفون: | De-Song Yang, Kai Huang, Min Su, Ting-Ting Wang, Si-Si Liu, Yang Xu, Wen-Xiang Wang |
| المصدر: | Journal of International Medical Research, Vol 49 (2021) |
| بيانات النشر: | SAGE Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Synchronous double primary lung squamous carcinoma (sDPLSCC) is rare and difficult to distinguish from metastatic disease, histopathologically. Owing to the heterogeneity of cancer, it is also difficult to select the optimal therapeutic strategy for patients with multiple primary lung cancer (MPLC). The present study reports a rare case of a 61-year-old male patient with sDPLSCC diagnosed using histology and genetic profiling. LSCC-related driver mutations were detected in this patient, and we reported the TP53 c.475G>C mutation, which has been detected in both breast cancer and hepatocellular carcinoma, but not previously in lung squamous carcinoma. Our findings provide further evidence supporting the necessity of genetic testing for primary tumor diagnosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2300 03000605 |
| Relation: | https://doaj.org/toc/1473-2300 |
| DOI: | 10.1177/03000605211018575 |
| URL الوصول: | https://doaj.org/article/e520781a6093464c8cb36af0849e603d |
| رقم الأكسشن: | edsdoj.520781a6093464c8cb36af0849e603d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14732300 03000605 |
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| DOI: | 10.1177/03000605211018575 |