دورية أكاديمية
A Mini-Review on the Common Antiviral Drug Targets of Coronavirus
| العنوان: | A Mini-Review on the Common Antiviral Drug Targets of Coronavirus |
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| المؤلفون: | Jun Wang, Qinghe Zhu, Xiaoxu Xing, Dongbo Sun |
| المصدر: | Microorganisms, Vol 12, Iss 3, p 600 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | coronavirus, virus targets, common mechanism, common antivirals, broad-spectrum, Biology (General), QH301-705.5 |
| الوصف: | Coronaviruses in general are a zoonotic pathogen with significant cross-species transmission. They are widely distributed in nature and have recently become a major threat to global public health. Vaccines are the preferred strategy for the prevention of coronaviruses. However, the rapid rate of virus mutation, large number of prevalent strains, and lag in vaccine development contribute to the continuing frequent occurrence of coronavirus diseases. There is an urgent need for new antiviral strategies to address coronavirus infections effectively. Antiviral drugs are important in the prevention and control of viral diseases. Members of the genus coronavirus are highly similar in life-cycle processes such as viral invasion and replication. These, together with the high degree of similarity in the protein sequences and structures of viruses in the same genus, provide common targets for antiviral drug screening of coronaviruses and have led to important advances in recent years. In this review, we summarize the pathogenic mechanisms of coronavirus, common drugs targeting coronavirus entry into host cells, and common drug targets against coronaviruses based on biosynthesis and on viral assembly and release. We also describe the common targets of antiviral drugs against coronaviruses and the progress of antiviral drug research. Our aim is to provide a theoretical basis for the development of antiviral drugs and to accelerate the development and utilization of commonly used antiviral drugs in China. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 12030600 2076-2607 |
| Relation: | https://www.mdpi.com/2076-2607/12/3/600; https://doaj.org/toc/2076-2607 |
| DOI: | 10.3390/microorganisms12030600 |
| URL الوصول: | https://doaj.org/article/e527af5b5eb74e32bbb2320d0b24bbba |
| رقم الأكسشن: | edsdoj.527af5b5eb74e32bbb2320d0b24bbba |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12030600 20762607 |
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| DOI: | 10.3390/microorganisms12030600 |