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C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome

التفاصيل البيبلوغرافية
العنوان: C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome
المؤلفون: Susanne Schulz, Selina Rehm, Axel Schlitt, Madlen Lierath, Henriette Lüdike, Britt Hofmann, Kerstin Bitter, Stefan Reichert
المصدر: Cells, Vol 12, Iss 13, p 1775 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Cytology
مصطلحات موضوعية: cardiovascular disease, C-reactive protein, genetic variants, prognostic factor, Cytology, QH573-671
الوصف: Background: Cardiovascular disease (CVD) is the primary cause of premature death and disability worldwide. There is extensive evidence that inflammation represents an important pathogenetic mechanism in the development and prognosis of CVD. C-reactive protein (CRP) is a potential marker of vascular inflammation and plays a direct role in CVD by promoting vascular inflammation. The objective of this study (ClinTrials.gov identifier: NCT01045070) was to assess the prognostic impact of CRP protein levels and genetic variants of CRP gene events on cardiovascular (CV) outcome (10-year follow-up) in patients suffering from CVD. Methods: CVD patients were prospectively included in this study (n = 1002) and followed up (10 years) regarding combined CV endpoint (CV death, death from stroke, myocardial infarction (MI), and stroke/transient ischemic attack (TIA)). CRP protein level (particle-enhanced immunological turbidity test) and genetic variants (rs1130864, rs1417938, rs1800947, rs3093077; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) after DNA extraction from EDTA-blood) were evaluated. Results: In survival analyses, increased CRP protein levels of ≥5 mg/L (log-rank test: p < 0.001, Cox regression: p = 0.002, hazard ratio = 1.49) and CT + TT genotype of rs1130864 (log-rank test: p = 0.041; Cox regression: p = 0.103, hazard ratio = 1.21) were associated with a weaker CV prognosis considering combined CV endpoint. Conclusions: Elevated CRP level and genetic variant (rs1130864) were proven to provide prognostic value for adverse outcome in CVD patients within the 10-year follow-up period.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2073-4409
28772059
Relation: https://www.mdpi.com/2073-4409/12/13/1775; https://doaj.org/toc/2073-4409
DOI: 10.3390/cells12131775
URL الوصول: https://doaj.org/article/52d287720594451e87eca1b4b8b5afde
رقم الأكسشن: edsdoj.52d287720594451e87eca1b4b8b5afde
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20734409
28772059
DOI:10.3390/cells12131775