دورية أكاديمية
The effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: a multi-site, non-randomized study
| العنوان: | The effect of omega-3 fatty acids on a biomarker of head trauma in NCAA football athletes: a multi-site, non-randomized study |
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| المؤلفون: | Jeffery L. Heileson, Anthony J. Anzalone, Aaron F. Carbuhn, Andrew T. Askow, Jason D. Stone, Stephanie M. Turner, Lyn M. Hillyer, David W. L. Ma, Joel A. Luedke, Andrew R. Jagim, Jonathan M. Oliver |
| المصدر: | Journal of the International Society of Sports Nutrition, Vol 18, Iss 1 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Sports medicine |
| مصطلحات موضوعية: | docosahexaenoic acid, american football, neurofilament light, concussion, brain, eicosapentaenoic acid, Nutrition. Foods and food supply, TX341-641, Sports medicine, RC1200-1245 |
| الوصف: | Background American-style football (ASF) athletes are at risk for cardiovascular disease (CVD) and exhibit elevated levels of serum neurofilament light (Nf-L), a biomarker of axonal injury that is associated with repetitive head impact exposure over the course of a season of competition. Supplementation with the w-3 fatty acid (FA) docosahexaenoic acid (DHA) attenuates serum Nf-L elevations and improves aspects of CVD, such as the omega-3 index (O3I). However, the effect of combining the w-3 FA eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) with DHA on, specifically, serum Nf-L in ASF athletes is unknown. Therefore, this study assessed the effect of supplemental w-3 FA (EPA+DPA+DHA) on serum Nf-L, plasma w-3 FAs, the O3I, and surrogate markers of inflammation over the course of a season. Methods A multi-site, non-randomized design, utilizing two American football teams was employed. One team (n = 3 1) received supplementation with a highly bioavailablew-3 FA formulation (2000mg DHA, 560mg EPA, 320mg DPA, Mindset®, Struct Nutrition, Missoula, MT) during pre-season and throughout the regular season, while the second team served as the control (n = 35) and did not undergo supplementation. Blood was sampled at specific times throughout pre- and regular season coincident w ith changes in intensity, physical contact, and changes in the incidence and severity of head impacts. Group differences were determined via a mixed-model between-within subjects ANOVA. Effect sizes were calculated using Cohen’s dfor all between-group differences. Significance was set a priori at p< .05. Results Compared to the control group, ASF athletes in the treatment group experienced large increases in plasma EPA (p < .001, d = 1.71) and DHA (p < .001, d = 2.10) which contributed to increases in the O3I (p < .001, d = 2.16) and the EPA:AA ratio (p = .001, d = 0.83) and a reduction in the w-6: w-3 ratio (p < .001, d = 1.80). w-3 FA supplementation attenuated elevations in Nf-L (p = .024). The control group experienced a significant increase in Nf-L compared to baseline at several measurement time points (T2, T3, and T4 [p range < .001 – .005, drange = 0.59-0.85]). Conclusions These findings suggest a cardio- and neuroprotective effect of combined EPA+DPA+DHA w-3 FA supplementation in American-style football athletes. Trial registration This trial was registered with the ISRCTN registry (ISRCTN90306741). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1550-2783 |
| Relation: | https://doaj.org/toc/1550-2783 |
| DOI: | 10.1186/s12970-021-00461-1 |
| URL الوصول: | https://doaj.org/article/53c55aa13a9f475f84aa3d759e90151d |
| رقم الأكسشن: | edsdoj.53c55aa13a9f475f84aa3d759e90151d |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 15502783 |
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| DOI: | 10.1186/s12970-021-00461-1 |