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Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality

التفاصيل البيبلوغرافية
العنوان: Standardized airway wall thickness Pi10 from routine CT scans of COPD patients as imaging biomarker for disease severity, lung function decline, and mortality
المؤلفون: Kathrin Kahnert, Rudolf A. Jörres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Jürgen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, Jürgen Biederer
المصدر: Therapeutic Advances in Respiratory Disease, Vol 17 (2023)
بيانات النشر: SAGE Publishing, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Diseases of the respiratory system, RC705-779
الوصف: Background: Chest computed tomography (CT) is increasingly used for phenotyping and monitoring of patients with COPD. The aim of this work was to evaluate the association of Pi10 as a measure of standardized airway wall thickness on CT with exacerbations, mortality, and response to triple therapy. Methods: Patients of GOLD grades 1–4 of the COSYCONET cohort with prospective CT scans were included. Pi10 was automatically computed and analyzed for its relationship to COPD severity, comorbidities, lung function, respiratory therapy, and mortality over a 6-year period, using univariate and multivariate comparisons. Results: We included n = 433 patients (61%male). Pi10 was dependent on both GOLD grades 1–4 ( p = 0.009) and GOLD groups A–D ( p = 0.008); it was particularly elevated in group D, and ROC analysis yielded a cut-off of 0.26 cm. Higher Pi10 was associated to lower FEV 1 % predicted and higher RV/TLC, moreover the annual changes of lung function parameters ( p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1753-4666
17534666
Relation: https://doaj.org/toc/1753-4666
DOI: 10.1177/17534666221148663
URL الوصول: https://doaj.org/article/5479cd8ba73d44879fe4dc190922a94a
رقم الأكسشن: edsdoj.5479cd8ba73d44879fe4dc190922a94a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17534666
DOI:10.1177/17534666221148663