دورية أكاديمية
TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy
العنوان: | TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy |
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المؤلفون: | Xiao Zhang, Fenyong Sun, Yongxia Qiao, Weisheng Zheng, Ya Liu, Yan Chen, Qi Wu, Xiangfan Liu, Guoqing Zhu, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang |
المصدر: | Cell Reports, Vol 21, Iss 5, Pp 1227-1239 (2017) |
بيانات النشر: | Elsevier, 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | Summary: Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required for YAP-dependent transcription and liver malignancy. Mechanistically, YAP function is stimulated by TFCP2 via a WW-PSY interaction. TFCP2 also maintains YAP stability by inhibiting βTrCP. Notably, genomic co-occupancy of YAP and TFCP2 is revealed. TFCP2 acts as a transcription co-factor that stimulates YAP transcription by facilitating YAP binding with YAP binding motif (YBF)-containing transcription factors. Interestingly, TFCP2 also stimulated the YAP-TEAD interaction and TEAD target gene expression. Finally, several genes co-regulated by YAP and TFCP2 that contribute to YAP-dependent tumorigenesis are identified and verified. Thus, we establish a model showing that TFCP2 acts as a YAP co-factor to maintain YAP-dependent transcription in liver cancer cells, suggesting that simultaneous targeting of both YAP and TFCP2 may be an effective therapeutic approach. : Zhang et al. reveal that TFCP2 acts as a YAP co-factor to stimulate YAP-dependent liver malignancy. YAP binds to TFCP2 via a WW-PSY interaction, which facilitates the binding of YAP to transcription factors that contain the YAP binding motif. These effects lead to the enhanced transcription of downstream co-regulated proto-oncogenes. Keywords: gene regulation, enhancer, YAP-dependent transcription factors, protein stability, βTrCP |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2211-1247 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2211124717314493; https://doaj.org/toc/2211-1247 |
DOI: | 10.1016/j.celrep.2017.10.017 |
URL الوصول: | https://doaj.org/article/553db43a831f446bb0d618e95424e92a |
رقم الأكسشن: | edsdoj.553db43a831f446bb0d618e95424e92a |
قاعدة البيانات: | Directory of Open Access Journals |
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