دورية أكاديمية
Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs
العنوان: | Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs |
---|---|
المؤلفون: | Seula Lim, Ye-In Oh, Jong-Woo Jeong, Kun-Ho Song, Tae-Sung Koo, Kyoung-Won Seo |
المصدر: | Journal of Advanced Veterinary and Animal Research, Vol 6, Iss 4, Pp 481-485 (2019) |
بيانات النشر: | Network for the Veterinarians of Bangladesh, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Veterinary medicine |
مصطلحات موضوعية: | ascorbic acid, dog, pharmacokinetics, Veterinary medicine, SF600-1100 |
الوصف: | Objective: We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs. Materials and Methods: The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration. Results: The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (p = 0.12990.7944). High-dose IV AA did not induce serious adverse events in dogs. Conclusion: The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs. [J Adv Vet Anim Res 2019; 6(4.000): 481-485] |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2311-7710 |
Relation: | http://www.ejmanager.com/fulltextpdf.php?mno=61679; https://doaj.org/toc/2311-7710 |
DOI: | 10.5455/javar.2019.f371 |
URL الوصول: | https://doaj.org/article/de55d51153be4aedb9ecfb842216ff79 |
رقم الأكسشن: | edsdoj.55d51153be4aedb9ecfb842216ff79 |
قاعدة البيانات: | Directory of Open Access Journals |
كن أول من يترك تعليقا!