دورية أكاديمية
أعرض في EDS

Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes

التفاصيل البيبلوغرافية
العنوان: Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes
المؤلفون: Peggy R. Biga, Mary N. Latimer, Jacob Michael Froehlich, Jean-Charles Gabillard, Iban Seiliez
المصدر: Biology Open, Vol 6, Iss 11, Pp 1720-1725 (2017)
بيانات النشر: The Company of Biologists, 2017.
سنة النشر: 2017
المجموعة: LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: Zebrafish, Histone modification, Atrophy, Autophagy, Myotube, Epigenetic, Science, Biology (General), QH301-705.5
الوصف: The zebrafish (Danio rerio) remains the teleost fish of choice for biological investigations due to the vast array of molecular tools and resources available. To better understand the epigenetic regulation of autophagy, we utilized a primary myotube culture system generated from isolated myogenic precursor cells (MPCs) from zebrafish grown under starvation conditions using a media devoid of serum and amino acids. Here, we report starvation-induced regulation of several autophagy-related genes (atg) expression and profile the distribution of H3K27me3, H3K9me3, and H3K4me3 marks along lc3b, atg4b and p62/sqstm1 loci. These data support epigenetic regulation of autophagy in response to starvation that suggests a level of regulation that can be sustained for chronic conditions via chromatin modification.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2046-6390
Relation: http://bio.biologists.org/content/6/11/1720; https://doaj.org/toc/2046-6390
DOI: 10.1242/bio.029090
URL الوصول: https://doaj.org/article/57e6cedc96254160adff297c7b0b5ad1
رقم الأكسشن: edsdoj.57e6cedc96254160adff297c7b0b5ad1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20466390
DOI:10.1242/bio.029090